Mark R. Viant PhD CChem MRSC CPhys MInstP CBiol MIBiol

School of Biosciences
The University of Birmingham
Birmingham, B15 2TT, U.K.
Phone:  +44-(0)121-414-2219
Fax:  +44-(0)121-414-5925
Email:  M.Viant@bham.ac.uk

ACADEMIC APPOINTMENTS

  • Reader in Metabolomics, School of Biosciences, University of Birmingham, UK, 2008-present.
  • NERC Advanced Fellow, School of Biosciences, University of Birmingham, UK, 2003-2008.
  • Lecturer, University of California, Davis, USA, Fall Quarter 2002.
  • Assistant Research Toxicologist (Research Faculty), University of California, Davis, USA, 2001-2003.
  • Postdoctoral Researcher, Department of Environmental Toxicology, University of California, Davis, USA, 1999-2001.
  • Postdoctoral Researcher, Department of Chemistry, University of California, Berkeley, USA, 1994-97.

EDUCATION

  • Ph.D., Chemical Physics, University of Southampton, UK, October 1994. Dissertation: The investigation of long-range atom-ion interactions by microwave and millimeter wave spectroscopy. Advisor: Prof. Alan Carrington FRS CBE
  • M.S., Avian Sciences (emphasis in Environmental Toxicology), University of California, Davis, USA, September 1999. Thesis: Analysis of the regulation of brain-derived neurotrophic factor mRNA expression in the developing avian hypothalamus. Advisor: Dr. D. Michael Fry.
  • B.Sc., Chemistry, 1st Class (Hons.), University of Southampton, UK, July 1991.

HONORS, AWARDS AND PROFESSIONAL QUALIFICATIONS

  • NERC Advanced Fellowship (2003).
  • Chartered Biologist, Institute of Biology (2002).
  • Chartered Physicist, Institute of Physics (2001).
  • Royal Commission for the Exhibition of 1851 Postdoctoral Research Fellowship (1994-96).
  • Chartered Chemist, Royal Society of Chemistry (1994).
  • British Petroleum Research Studentship (1991-94).
  • David Runciman Boyd prize, University of Southampton, U.K. (1991).
  • N. K. Adam prize, University of Southampton, U.K. (1990).
  • John Scott-Montagu prize, University of Southampton, U.K. (1989).

PROFESSIONAL SERVICE

  • Guest Editor for special issue of Metabolomics on "Environmental Metabolomics" (2009).
  • Member of NERC Peer Review College (2008-present).
  • Editorial board of Environmental Toxicology and Chemistry (2007-present).
  • Co-chair of Environmental Context Working Group of the Metabolomics Standards Initiative (2006-present).
  • Invited Expert in Metabolomics: Joint SETAC-SOT Pellston Workshop on Molecular Biology and Risk Assessment: Evaluation of the Potential Roles of Genomics in Regulatory Ecotoxicology, Pellston, Michigan, USA, 18th-22nd September 2005.
  • Editorial board of Metabolomics (2004-present).
  • Invited Expert in Metabolomics: OECD/IPCS Workshop on Toxicogenomics, Kyoto, Japan, 13th-15th October 2004.
  • Invited Expert in Metabolomics: Joint SETAC-SOT Pellston Workshop on Emerging Molecular and Computational Approaches for Cross Species Extrapolations, Portland, Oregon, USA, 18th-22nd July 2004.

PROFESSIONAL AFFILIATIONS

  • Member of the Metabolomics Society (2005-present).
  • Member of the Institute of Biology (2002-present).
  • Member of the Institute of Physics (2001-present).
  • Member of the Society of Environmental Toxicology and Chemistry (2000-present).
  • Member of the Royal Society of Chemistry (1994-present).

 

RESEARCH GRANTS IN UK

As Principal Investigator
2008-09 Automated metabolite identification and quantification using J-resolved NMR spectroscopy, BBSRC (BB/F016298/1). £92,700.

2007-08 Cellular metabolism in human liver transplants: An assessment by FT-ICR mass spectrometry-based metabolomics and in vivo microdialysis, Pilot project funding from MRC/EPSRC Institutional Discipline Bridging Award to Birmingham. £2,304.

2006-09 Diagnosing toxicant specific disruption of sexual development in wild fish using metabolomics (with C. Tyler et al., Exeter), NERC (NE/D002508/1). £404,609.

2005-08 Integrated metabolomic and transcriptomic studies of stress response mechanisms in flatfish liver, BBSRC CASE Award from the Centre for Environment, Fisheries and Aquaculture Science. £11,700.

2004-07 Application of metabolomics to the development of a predictive biomarker model for Mytilus edulis, NERC CASE Award from the Centre for Environment, Fisheries and Aquaculture Science. £3,000.

2003-08 Development of a predictive biomarker model for the marine and estuarine environments using state-of-the-art NMR-based metabolomics and bioinformatic techniques, NERC Advanced Fellowship (NER/J/S/2002/00618). £296,740.

As Co-Investigator
2008-12 HWB-NMR: a national resource for biomolecular research (with M. Overduin et al.), Wellcome Trust (083796), £497,000.

2008-08 New spectrometers for centres of excellence in biomedical research (with H. Cooper, U. Günther and M. Overduin et al.), The Wolfson Foundation, £500,000.

2008-09 Distinguishing toxic from adaptive responses in fish using “omics” – a key need for integration of toxicogenomics into environmental risk assessment (with J. K. Chipman et al.), NERC (NE/F008465/1). £48,716.

2008-09 Data mining and integration strategies for ecotoxicogenomics (with T. Ebbels et al., Imperial College), NERC (NE/F001398/1). £164,642.

2007-08 Purchase of a 600 MHz ACAS magnet and cryogenic probe for high throughput metabolomics and ligand discovery (with M. Overduin et al.), BBSRC REI (BB/E013198/1). £255,686.

2006-07 High throughput systems biology analysis, modelling and simulation of large biological data sets (with F. Falciani et al.), BBSRC REI (BB/D524624/1). £108,488.

2005-08 International Consortium on Fish Toxicogenomics (with J. K. Chipman et al.), NERC (NE/D000793/1). £147,907.

2005-07 Molecular and genomic ecotoxicology knowledge transfer for environmental chemical risk assessment (with J. K. Chipman et al.), NERC Transfer of Knowledge (NE/D000807/1). £59,674.

2005-06 Cryogenic probe for the Henry Wellcome Building for Biomolecular NMR Spectroscopy (with M. Overduin et al.), Wellcome Trust (077311). £180,112.

2005-08 Metabolic and transcriptional pathway inference using State Space models: An application to understanding acid response (with F. Falciani et al.), BBSRC. £257,512.

2005-09 MOTET: Metabolomics and Oncology, Transfer of European Technology (with U Günther and C Bunce), EU 6th Framework Marie Curie Host Fellowships for the Transfer of Knowledge. €950,000.

2005-08 Identifying and defining the bases of individual and population susceptibility and adaptation to environmental pollutants in fish: An integrated ‘omic’ approach (with J. K. Chipman et al.), NERC. £1,582,009.

2004-05 Establishment of a European High Throughput NMR Centre for Metabolomics and Ligand Discovery (with M. Overduin et al.), BBSRC. £200,000.

RESEARCH GRANTS IN USA

As Principal Investigator

2003-05 Of Mice and Metabolomics: Quantifying Susceptibility to Endocrine Disruption (with M. G. Miller and J. L. Spearow, UC Davis), NIEHS Center for Environmental Health Sciences Pilot Projects Program. $29,443.

2003-04 NMR-based Metabolomic Approach for Investigating Developmental Toxicity in Fish Embryos, UC Davis NMR Facility Award. $2,000.

2002-03 The Identification of Novel Biomarkers for Early-Stage Withering Syndrome in Red Abalone using NMR-Based Metabonomics, UC Davis NMR Facility Award. $1,900.

As Co-Investigator
2004-06 Acute and Chronic Effects of Crude Oil and Dispersed Oil on Chinook Salmon Smolts (with R. S. Tjeerdema, UC Davis), National Oceanic and Atmospheric Administration - University of New Hampshire Cooperative Institute for Coastal and Estuarine Environmental Technology. $150,000.

2004-06 Influence of Temperature on the Pharmacokinetics and Efficacy of Oxytetracycline in RLP-Infected Abalone (with R. S. Tjeerdema, UC Davis, C. S. Friedman, University of Washington, and J. D. Moore, UC Davis Bodega Marine Laboratory), National Oceanic and Atmospheric Administration, U.S. Department of Commerce, National and California Sea Grant College Programs. $102,282.

2003-05 Acute and Chronic Effects of Crude Oil and Dispersed Oil on Chinook Salmon Smolts (with R. S. Tjeerdema, UC Davis), UC Wildlife Health Center, Oiled Wildlife Care Network. $106,111.

2001-03 Characterizing the Role of Environmental Stressors in the Development of Withering Syndrome in Red Abalone (with R. S. Tjeerdema and C. S. Friedman, UC Davis), National Oceanic and Atmospheric Administration, U.S. Department of Commerce, National and California Sea Grant College Programs. $166,395.

2001-02 The Microbial Degradation of Pesticides Important to Rice Culture (with R. S. Tjeerdema and D. G. Crosby, UC Davis), UC Rice Research Board. $35,968.

2001-02 Occurrence and Fate of the New Algal Toxin Azaspiracid in California Coastal Waters (with R. S. Tjeerdema and S. J. Gee, UC Davis), UC Toxic Substances Research & Teaching Program. $24,415.

2000-01 The Microbial Degradation of Pesticides Important to Rice Culture (with R. S. Tjeerdema and D. G. Crosby, UC Davis), UC Rice Research Board. $27,010.

PUBLIC SERVICE AND OUTREACH

INTERNATIONAL INVITED LECTURES

  • ‘Background variability in the mussel metabolome’, NERC International Workshop On Fish Toxicogenomics “Moving into monitoring and regulation”, Vancouver, Canada, April 2008.

  • ‘International NMR-based environmental metabolomics intercomparison exercise’, NERC International Workshop On Fish Toxicogenomics “Moving into monitoring and regulation”, Vancouver, Canada, April 2008.

  • ‘What can metabolic profiling offer environmental toxicology?’, Eleventh International Congress of Toxicology, Montreal, Canada, July 2007.

  • ‘From peaks to knowledge: Interpreting multivariate metabolic models’, Third Annual International Conference of The Metabolomics Society, Manchester, UK, June 2007.

  • 'Environmental Metabolomics: Applications of NMR and mass spectrometry’, European Commission Workshop on Omics and the Environment, JRC, Ispra, Italy, March 2007.

  • ‘Development of FT-ICR mass spectrometry based metabolomics’, Advances in Metabolic Profiling, London, UK, October 2006.

  • ‘Characterising the stress responses of aquatic organisms using metabolomics’, Annual Meeting of the European Society of Comparative Physiology and Biochemistry, Antwerp, Belgium, September 2006.

  • ‘Applications of NMR spectroscopy and advanced mass spectrometry in environmental metabolomics’, Princeton ACS 2006 Seminar Series, Princeton University, New Jersey, USA, June 2006.

  • ‘Applications of metabolomics to aquatic toxicology’, Invited Seminar, NRC Institute of Marine Biosciences, Halifax, Nova Scotia, Canada, May 2006.

  • ‘Applications of NMR spectroscopy and advanced mass spectrometry in environmental metabolomics’, Canadian Chemistry Conference, Halifax, Nova Scotia, Canada, May 2006.

  • ‘Comparison of experimental strategies in NMR metabolomics: Limitations and solutions’, Annual Meeting of the Society of Environmental Toxicology and Chemistry, Baltimore, Maryland, USA, November 2005.

  • ‘What can metabolomics offer chemical risk assessment?’, Joint SETAC-SOT Pellston Workshop on Molecular Biology and Risk Assessment: Evaluation of the Potential Roles of Genomics in Regulatory Ecotoxicology, Pellston, Michigan, USA, September 2005.

  • ‘The Nuts & Bolts of NMR Metabolomics: from Sample Preparation to Spectral Processing’, Training Workshop on Metabolomics & Nutrition, Trinity Centre for Health Sciences, St. James’s Hospital, Dublin, Ireland, January 2005.

  • ‘Environmental Metabolomics’, OECD/IPCS Workshop on Toxicogenomics, Kyoto, Japan, October 2004.

  • ‘Applications of Metabolic Fingerprinting for the Diagnosis of Environmental Diseases’, The Consortium for Post-Genome Science, Conference on ‘Genomes to Systems’, Manchester, UK, September 2004.


PUBLICATIONS – PEER REVIEWED ARTICLES

65. M. R. Viant, D. Bearden, J. G. Bundy, I. Burton, T. W. Collette, D. R. Ekman, V. Ezernieks, T. Karakach, C. Y. Lin, S. Rochfort, J. S. de Ropp, Q. Teng, R. S. Tjeerdema, J. Walter, H. Wu, International NMR-based Environmental Metabolomics Intercomparison Exercise. Environ. Sci. Technol. (in press).

64. A. D. Southam, J. M. Easton, G. D. Stentiford, C. Ludwig, T. N. Arvanitis, M. R. Viant, Metabolic changes in flatfish hepatic tumours revealed by NMR-based metabolomics and metabolic correlation networks. J. Prot. Res. (in press).

63. N. S. Taylor, R. J. M. Weber, A. D. Southam, T. G. Payne, O. Hrydziuszko, T. N. Arvanitis, M. R. Viant, A new approach to toxicity testing in Daphnia magna: Application of high throughput FT-ICR mass spectrometry metabolomics. Metabolomics (in press).

62. T. C. Hawes, A. Hines, M. R. Viant, J. S. Bale, M. R. Worland, P. Convey, Metabolomic fingerprint of cryo-stress in a freeze-tolerant insect. Cryoletters (in press).

61. M. R. Viant, Recent developments in environmental metabolomics. Molecular Biosystems 4, 980-986 (2008).

60. A.-H. Emwas, S. Tiziani, M. R. Viant and U. L. Günther, Optimised Metabolite Extraction from Blood Serum for 1H Nuclear Magnetic Resonance Spectroscopy. Anal. Biochem. 377, 16-23 (2008).

59. Y. Xi, J. S. de Ropp, M. R. Viant, D. L. Woodruff and P. Yu, Improved Screening for Metabolites in Complex Mixtures using HSQC NMR Spectroscopy. Anal. Chim. Acta 614, 127-133 (2008).

58. S. Tiziani, A. Lodi, C. Ludwig, H. M. Parsons and M. R. Viant, Effects of the application of different window functions to processing of 1H J-resolved NMR spectra for metabolomics. Anal. Chim. Acta 610, 80-88 (2008).

57. H. Wu, A. D. Southam, A. Hines and M. R. Viant, High throughput tissue extraction protocol for NMR and mass spectrometry based metabolomics. Anal. Biochem. 372, 204-212 (2008).

56. M. R. Viant, C. Ludwig, S. Rhodes, U. L. Günther and D. Allaway, Validation of a urine metabolome fingerprint in dog for phenotypic classification. Metabolomics 3, 453-463 (2007).

55. G.-C. Lee, J. de Ropp, M. R. Viant, D. L. Woodruff and P. Yu, Heuristic Search for 2D NMR Alignment to Support Metabolite Identification, Lecture Notes In Computer Science 4614, 447-458 (2007).

54. A. Hines, W. H. Yeung, J. Craft, M. Brown, J. Kennedy, J. Bignell, G. D. Stentiford and M. R. Viant, Comparison of Histological, Genetic, Metabolomic and Lipid-based Methods for Sex Determination in Marine Mussels. Anal. Biochem. 369, 175-186 (2007).

53. S.-A. Sansone, D. Schober, H. J. Atherton, O. Fiehn, H. Jenkins, P. Rocca-Serra, D. V. Rubtsov, I. Spasic, L. Soldatova, C. Taylor, A. Tseng and M. R. Viant, Metabolomics Standards Initiative: Ontology Working Group work in progress. Metabolomics 3, 249-256 (2007).

52. D. V. Rubtsov, H. Jenkins, C. Ludwig, J. Easton, M. R. Viant, U. Guenther, J. L. Griffin and N. Hardy, Proposed Reporting Requirements for the Description of NMR-based Metabolomics Experiments. Metabolomics 3, 223-229 (2007).

51. L. W. Sumner, A. Amberg, D. Barrett, M. H. Beale, R. Beger, C. A. Daykin, T. W.-M. Fan, O. Fiehn, R. Goodacre, J. L. Griffin, T. Hankemeier, N. Hardy, J. Harnly, R. Higashi, J. Kopka, A. N. Lane, J. C. Lindon, P. Marriott, A. W. Nicholls, M. D. Reily, J. J. Thaden and M. R. Viant, Proposed Minimum Reporting Standards for Chemical Analysis. Metabolomics 3, 211-221 (2007).

50. N. Morrison, D. Bearden, J. G. Bundy, T. Collette, F. Currie, M. P. Davey, N. S. Haigh, D. Hancock, O. A. H. Jones, S. Rochfort, S.-A. Sansone, D. Štys, Q. Teng, D. Field and M. R. Viant, Standard Reporting Requirements for Biological Samples in Metabolomics Experiments: Environmental Context. Metabolomics 3, 203-210 (2007).

49. H. M. Parsons, C. Ludwig, U. L. Günther and M. R. Viant, Improved classification accuracy in 1- and 2-dimensional NMR metabolomics data using the variance stabilising generalised logarithm transformation. BMC Bioinformatics 8, 234 (2007).

48. R. E. Blunt, K. A. Walsh, D. K. Ashton, M. R. Viant and J. K. Chipman, Knowledge Transfer Initiative between Molecular Biologists and Environmental Researchers and Regulators. Environ. Sci. Pollut. Res. 14, 293-296 (2007).

47. A. D. Southam, T. G. Payne, H. J. Cooper, T. N. Arvanitis, M. R. Viant, Spectral Stitching Method Increases the Dynamic Range and Mass Accuracy of Wide-scan Direct Infusion nano-Electrospray Fourier Transform Ion Cyclotron Resonance Mass Spectrometry-based Metabolomics. Anal. Chem. 79, 4595-4602 (2007).

46. A. Hines, G. S. Oladiran, J. P. Bignell, G. D. Stentiford and M. R. Viant, Direct Sampling of Organisms from the Field and Knowledge of their Phenotype: Key Recommendations for Environmental Metabolomics. Env. Sci. Technol. 41, 3375-3381 (2007).

45. M. A. Turner, M. R. Viant, S. J. Teh and M. L. Johnson, Developmental rates, structural asymmetry and metabolic fingerprints of steelhead trout (Oncorhynchus mykiss) eggs incubated at two temperatures. Fish Physiol. Biochem.33, 59-72 (2007).

44. C.-Y. Lin, H. Wu, R. S. Tjeerdema and M. R. Viant, Evaluation of metabolite extraction strategies from tissue samples using NMR metabolomics. Metabolomics 3, 55-67 (2007).

43. M. R. Viant, Metabolomics of aquatic organisms: the new omics on the block. Mar. Ecol. Prog. Series 332, 301-306 (2007).

42. Y. Xi, J. de Ropp, M. R. Viant, D. L. Woodruff and Ping Yu, Automated Identification of Metabolites in Complex Mixtures by Pseudo-likelihood using 2D COSY NMR Spectroscopy. Metabolomics 2, 221-233 (2006).

41. E. S. Rosenblum, R. S. Tjeerdema and M. R. Viant, Effects of Temperature on Host-Pathogen-Drug Interactions in Red Abalone, Haliotis rufescens, Determined by 1H NMR Metabolomics. Env. Sci. Technol. 40, 7077-7084 (2006).

40. I. Werner, M. R. Viant, E. S. Rosenblum, A. S. Gantner, R. S. Tjeerdema and M. L. Johnson, Cellular responses to temperature stress in steelhead trout (Onchorynchus mykiss) parr with different rearing histories. Fish Physiol. Biochem. 32, 261-273 (2006).

39. C.-Y. Lin, M. R. Viant and R. S. Tjeerdema, Metabolomics: Methodologies and Applications in the Environmental Sciences. J. Pestic. Sci. 31, 245-251 (2006).

38. M. R. Viant, C. A. Pincetich and R. S. Tjeerdema, Metabolic effects of dinoseb, diazinon and esfenvalerate in eyed eggs and alevins of Chinook salmon (Oncorhynchus tshawytscha) determined by 1H NMR metabolomics. Aquat. Toxicol. 77, 359-371 (2006).

37. M. R. Viant, C. A. Pincetich, D. E. Hinton and R. S. Tjeerdema, Toxic Actions of Dinoseb in Medaka (Oryzias latipes) Embryos as Determined by in vivo 31P NMR, HPLC-UV and 1H NMR Metabolomics. Aquat. Toxicol. 76, 329-342 (2006).

36. M. R. Viant, B. G. Lyeth, M. G. Miller and R. F. Berman, An NMR Metabolomic Investigation of Early Metabolic Disturbances Following Traumatic Brain Injury in a Mammalian Model, NMR in Biomedicine 18, 507-516 (2005).

35. G. D. Stentiford, M. R. Viant, D. G. Ward, P. J. Johnson, A. Martin, W. Wei, H. J. Cooper, B. P. Lyons and S. W. Feist, Liver Tumours in Wild Flatfish: A Histopathological, Proteomic and Metabolomic Study, OMICS - Journal of Integrative Biology 9, 281-299 (2005).

34. H. A. Harker, M. R. Viant, F. N. Keutsch, E. A. Michael, R. P. McLaughlin and R. J. Saykally, Water Pentamer: Characterization of the Torsional-Puckering Manifold by Terahertz VRT Spectroscopy, J. Phys. Chem. A 109, 6483-6497 (2005).

33. E.S. Rosenblum, M. R. Viant, B. M. Braid, J. D. Moore, C. S. Friedman and R. S. Tjeerdema, Characterizing the Metabolic Actions of Natural Stresses in the California Red Abalone, Haliotis rufescens using 1H NMR Metabolomics. Metabolomics 1, 199-209 (2005).

32. M. R. Viant, J. G. Bundy, C. A. Pincetich, J. S. de Ropp and R. S. Tjeerdema, NMR-Derived Developmental Metabolic Trajectories: An Approach for Visualizing the Toxic Actions of Trichloroethylene during Embryogenesis. Metabolomics. 1, 149-158 (2005).

31. C. A. Pincetich, M. R. Viant, D. E. Hinton and R. S. Tjeerdema, Metabolic Changes in Japanese Medaka (Oryzias latipes) during Embryogenesis and Hypoxia as determined by in vivo 31P NMR, Comp. Biochem. Physiol. C 140, 103-113 (2005).

30. K. R. Schmelzer, C. S. Johnson, M. R. Viant, J. F. Williams and R. S. Tjeerdema, Influence of Organic Carbon on Reductive Dechlorination of Thiobencarb in California Rice Field Soils, Pest Manag. Sci. 61, 68-74 (2005).

29. P. L. TenBrook, M. R. Viant, D. M. Holstege, J. F. Williams and R. S. Tjeerdema, Characterization of California Rice Field Soils Susceptible to Delayed Phytotoxicity Syndrome, Bull. Environ. Contam. Toxicol. 73, 448-456 (2004).

28. P. V. Purohit, D. M. Rocke, M. R. Viant and D. L. Woodruff,Discrimination Models using Variance Stabilizing Transformation of Metabolomic NMR Data, OMICS 8,118-130 (2004).

27. M. R. Viant, I. Werner, E. S. Rosenblum, A. S. Gantner, R. S. Tjeerdema and M. L. Johnson, Correlation Between Heat-Shock Protein Induction and Reduced Metabolic Condition in Juvenile Steelhead Trout (Oncorhynchus mykiss) Chronically Exposed to Elevated Temperature, Fish Physiol. Biochem. 29, 159-171 (2003).

26. M. R. Viant, E. S. Rosenblum and R. S. Tjeerdema, NMR-Based Metabolomics: A Powerful Approach for Characterizing the Effects of Environmental Stressors on Organism Health, Env. Sci. Technol. 37, 4982-4989 (2003).

25. M. R. Viant, Improved Methods for the Acquisition and Interpretation of NMR Metabolomic Data, Biochem. Biophys. Res. Comm. 310, 943-948 (2003).

24. P. L. TenBrook, S. M. Kendall, M. R. Viant and R. S. Tjeerdema, Toxicokinetics and Biotransformation of p-Nitrophenol in Red Abalone (Haliotis rufescens), Aquat. Toxicol. 62, 329-336 (2003).

23. J. R. Millam, C. B. Craig-Veit, M. E. Batchelder, M. R. Viant, T. M. Herbeck and L. W. Woods, An Avian Bioassay for Environmental Estrogens: The Growth Response of Zebra Finch (Taeniopygia guttata) Chick Oviduct to Oral Estrogens, Environ. Toxicol. Chem. 21, 2663-2668 (2002).

22. M. R. Viant, C. A. Pincetich, J. H. Walton, R. S. Tjeerdema and D. E. Hinton, Utilizing in vivo Nuclear Magnetic Resonance Spectroscopy to Study Sublethal Stress in Aquatic Organisms, Mar. Environ. Res. 54, 553-557 (2002).

21. M. R. Viant, J. H. Walton, P. L. TenBrook and R. S. Tjeerdema, Sublethal Actions of Copper in Abalone (Haliotis rufescens) as Characterized by in vivo 31P NMR, Aquat. Toxicol. 57, 139-151 (2002).

20. A. E. Quaglino, C. B. Craig-Veit, M. R. Viant, A. L. Erichsen, D. M. Fry and J. R. Millam, Oral Estrogen Masculinizes Female Zebra Finch Song System, Horm. Behav. 41, 236-241 (2002).

19. M. R. Viant, E. S. Rosenblum and R. S. Tjeerdema, Optimized Method for the Determination of Phosphoarginine in Abalone Tissue by High-performance Liquid Chromatography, J. Chromatogr. B 765, 107-111 (2001).

18. M. R. Viant, J. H. Walton and R. S. Tjeerdema, Comparative Sublethal Actions of 3-Trifluoromethyl-4-nitrophenol in Marine Molluscs as Measured by in vivo 31P NMR, Pestic. Biochem. Physiol. 71, 40-47 (2001).

17. F. N. Keutsch, R. S. Fellers, M. G. Brown, M. R. Viant, P. B. Petersen and R. J. Saykally, Hydrogen Bond Breaking Dynamics of the Water Trimer in the Translational and Librational Band Region of Liquid Water, J. Am. Chem. Soc. 123, 5938-5941 (2001).

16. F. N. Keutsch, R. S. Fellers, M. R. Viant and R. J. Saykally, Far-infrared laser VRT Spectroscopy of Water Clusters in the Librational Band Region of Liquid Water, J. Chem. Phys. 114, 4005-4015 (2001).

15. M. R. Viant, J. R. Millam, M. E. Delany and D. M. Fry, Regulation of Brain-derived Neurotrophic Factor mRNA Levels in Avian Hypothalamic Slice Cultures, Neuroscience 99, 373-380 (2000).

14. M. G. Brown, M. R. Viant and R. J. Saykally, Far Infrared Laser VRT Spectroscopy of Water Clusters, Proceedings of the 1997 NATO Advanced Study Institute Conference on Recent Theoretical and Experimental Advances in Hydrogen Bonded Clusters, Heraklion, Crete, Greece, S. S. Xantheas (Ed.), pp. 101-108 (2000).

13. M. G. Brown, M. R. Viant, R. P. McLaughlin, C. J. Keoshian, J. D. Cruzan, R. J. Saykally and A. van der Avoird, Quantitative Characterization of the Water Trimer Torsional Manifold by Terahertz Laser Spectroscopy and Theoretical Analysis: (H2O)3, J. Chem. Phys. 111, 7789-7800 (1999).

12. M. R. Viant, M. G. Brown, J. D. Cruzan, R. J. Saykally, M. Geleijns and A. van der Avoird, Quantitative Characterization of the (D2O)3 Torsional Manifold by Terahertz Laser Spectroscopy and Theoretical Analysis, J. Chem. Phys. 110, 4369-4381 (1999).

11. J. D. Cruzan, M. R. Viant, M. G. Brown, D. D. Lucas, K. Liu and R. J. Saykally, Terahertz Laser Vibration-rotation-tunneling Spectrum of the Water Pentamer-d10: Constraints on the Bifurcation Tunneling Dynamics, Chem. Phys. Lett. 292, 667-676 (1998).

10. M. R. Viant, J. D. Cruzan, D. D. Lucas, M. G. Brown, K. Liu and R. J. Saykally, Pseudorotation in Water Trimer Isotopomers using Terahertz Laser Spectroscopy, J. Phys. Chem. A 101, 9032-9041 (1997).

9. J. D. Cruzan, M. R. Viant, M. G. Brown and R. J. Saykally, Terahertz Laser Vibration-rotation-tunneling Spectroscopy of the Water Tetramer, J. Phys. Chem. A 101, 9022-9031 (1997).

8. K. Liu, M. G. Brown, M. R. Viant, J. D. Cruzan and R. J. Saykally, Far-infrared VRT Spectroscopy of two Water Trimer Isotopomers: Vibrationally Averaged Structures and Rearrangement Dynamics, Mol. Phys. 89, 1373-1396 (1996).

7. K. Liu, R. S. Fellers, M. R. Viant, R. P. McLaughlin, M. G. Brown and R. J. Saykally, A Long Path Length Pulsed Slit Valve Appropriate for High Temperature Operation: Infrared Spectroscopy of Jet-cooled Large Water Clusters and Nucleotide Bases, Rev. Sci. Instrum. 67, 410-416 (1996).

6. M. R. Viant, R. S. Fellers, R. P. McLaughlin and R. J. Saykally, Infrared Laser Spectroscopy of Uracil in a Pulsed Slit Jet, J. Chem. Phys. 103, 9502-9505 (1995).

5. A. Carrington, J. M. Hutson, M. M. Law, C. A. Leach, A. J. Marr, A. M. Shaw and M. R. Viant, Microwave Spectroscopy and Interaction Potential of the Long-range He…Ar+ Ion, J. Chem. Phys. 102, 2379-2403 (1995).

4. A. Carrington, C. A. Leach, A. J. Marr, C. H. Pyne, A. M. Shaw, M. R. Viant and Y. D. West, Near-dissociation Microwave Spectra of Rare-gas Diatomic Ions, Chem. Phys. Lett. 212, 473-479 (1993).

3. A. Carrington, C. A. Leach and M. R. Viant, Nuclear Hyperfine Structure in the Electronic Millimeter Wave Spectrum of H2+, Chem. Phys. Lett. 206, 77-82 (1993).

2. A. Carrington, C. A. Leach, R. E. Moss, T. C. Steimle, M. R. Viant and Y. D. West, Microwave Electronic Spectroscopy, Electric Field Dissociation and Photofragmentation of the H2+ Ion, J. Chem. Soc. Faraday Trans. 89, 603-614 (1993).

1. A. Carrington, R. A. Kennedy, C. A. Leach, A. J. Marr, I. R. McNab, R. E. Moss, C. H. Pyne, M. R. Viant and Y. D. West, Spectroscopy of HD+ in High Angular Momentum States, Chem. Phys. 166, 145-166 (1992).

TEACHING EXPERIENCE

Lectures presented in UK

  • Bio331 - Omics (Undergraduate class). Three lectures on ‘Metabolomics’, University of Birmingham, 2004-present.
  • MSc Toxicology course (Graduate class). Two lectures on ‘Metabolomics’, University of Birmingham, 2004-present.
  • Biosciences Graduate School lecture on ‘Metabolomics’, 2005.
  • Medicine Graduate School lecture on ‘Metabolomics’, 2005.

Courses taught in USA

  • ETX 220 - Analysis of Toxicants (Graduate class). Co-instructed with Prof. Judi Charles. University of California, Davis, Fall Quarter 2002.

Lectures presented in USA

  • PTX 203 – Principles of Pharmacology and Toxicology (Graduate class). Presented lectures on ‘Metabolomics: basic methodology and tools’ and ‘Metabolomics: applications’. University of California, Davis, May 2003.
  • EAD 289D - Statistical Bioinformatics (Graduate class). Presented lecture on ‘NMR-based Metabolomics’. University of California, Davis, February 2003.
  • MGT 281 - Systems Analysis and Design (Professional class). Presented lecture on ‘Processing NMR-based Metabonomic Data’ and participated in class project. University of California, Davis, October 2002.
  • ETX 220 - Analysis of Toxicants (Graduate class). Presented lecture on ‘In Vivo NMR Spectroscopy’. University of California, Davis, November 2000 and 2001.
  • ETX 10 - Introduction to Environmental Toxicology (Undergraduate class). Presented lecture on ‘Chemical Sex Changes: Endocrine Disruption’. University of California, Davis, May 2000, 2001, 2002 and 2003.