Environmental Metabolomics

Reviews
 

J. G. Bundy, M. P. Davey, M. R. Viant, Environmental metabolomics: A critical review and future perspectives. Metabolomics 5, 3-21 (2009).

M. R. Viant, Recent developments in environmental metabolomics. Molecular Biosystems 4, 980-986 (2008).

M. R. Viant, Metabolomics of aquatic organisms: the new omics on the block. Mar. Ecol. Prog. Series 332, 301-306 (2007).

C.-Y. Lin, M. R. Viant and R. S. Tjeerdema, Metabolomics: Methodologies and Applications in the Environmental Sciences. J. Pestic. Sci. 31, 245-251 (2006).
 

Research Articles
 

M. R. Viant, D. W. Bearden, J. G. Bundy, I. W. Burton, T. W. Collette, D. R. Ekman, V. Ezernieks, T. K. Karakach, C. Y. Lin, S. Rochfort, J. S. de Ropp, Q. Teng, R. S. Tjeerdema, J. A. Walter, H. Wu, International NMR-based Environmental Metabolomics Intercomparison Exercise. Environ. Sci. Technol. 43, 219-225 (2009).

A. D. Southam, J. M. Easton, G. D. Stentiford, C. Ludwig, T. N. Arvanitis, M. R. Viant, Metabolic changes in flatfish hepatic tumours revealed by NMR-based metabolomics and metabolic correlation networks. J. Proteome Res. 7, 5277-5285 (2008).

T. C. Hawes, A. Hines, M. R. Viant, J. S. Bale, M. R. Worland, P. Convey, Metabolomic fingerprint of cryo-stress in a freeze-tolerant insect. Cryoletters 29, 505-515 (2008).

S. Tiziani, A.-H. Emwas, A. Lodi, C. Ludwig, C. M. Bunce, M. R. Viant and U. L. Günther, Optimised Metabolite Extraction from Blood Serum for 1H Nuclear Magnetic Resonance Spectroscopy. Anal. Biochem. 377, 16-23 (2008).

Y. Xi, J. S. de Ropp, M. R. Viant, D. L. Woodruff and P. Yu, Improved Screening for Metabolites in Complex Mixtures using HSQC NMR Spectroscopy. Anal. Chim. Acta 614, 127-133 (2008).

S. Tiziani, A. Lodi, C. Ludwig, H. M. Parsons and M. R. Viant, Effects of the application of different window functions and projection methods on processing of 1H J-resolved nuclear magnetic resonance spectra for metabolomics. Anal. Chim. Acta 610, 80-88 (2008).

H. Wu, A. D. Southam, A. Hines and M. R. Viant, High throughput tissue extraction protocol for NMR- and MS-based metabolomics. Anal. Biochem. 372, 204-212 (2008).

A. Hines, W. H. Yeung, J. Craft, M. Brown, J. Kennedy, J. Bignell, G. D. Stentiford and M. R. Viant, Comparison of Histological, Genetic, Metabolomic and Lipid-based Methods for Sex Determination in Marine Mussels. Anal. Biochem. 369, 175-186 (2007).

H. M. Parsons, C. Ludwig, U. L. Günther and M. R. Viant, Improved classification accuracy in 1- and 2-dimensional NMR metabolomics data using the variance stabilising generalised logarithm transformation. BMC Bioinformatics 8, 234 (2007).

R. E. Blunt, K. A. Walsh, D. K. Ashton, M. R. Viant and J. K. Chipman, Knowledge Transfer Initiative between Molecular Biologists and Environmental Researchers and Regulators. Environ. Sci. Pollut. Res. 14, 293-296 (2007).

A. D. Southam, T. G. Payne, H. J. Cooper, T. N. Arvanitis, M. R. Viant, Spectral Stitching Method Increases the Dynamic Range and Mass Accuracy of Wide-scan Direct Infusion nano-Electrospray Fourier Transform Ion Cyclotron Resonance Mass Spectrometry-based Metabolomics. Anal. Chem. 79, 4595-4602 (2007).

A. Hines, G. S. Oladiran, J. P. Bignell, G. D. Stentiford and M. R. Viant, Direct Sampling of Organisms from the Field and Knowledge of their Phenotype: Key Recommendations for Environmental Metabolomics. Env. Sci. Technol. 41, 3375-3381 (2007).

M. A. Turner, M. R. Viant, S. J. Teh and M. L. Johnson, Developmental rates, structural asymmetry and metabolic fingerprints of steelhead trout (Oncorhynchus mykiss) eggs incubated at two temperatures. Fish Physiol. Biochem. 33, 59-72 (2007).

C.-Y. Lin, H. Wu, R. S. Tjeerdema and M. R. Viant, Evaluation of metabolite extraction strategies from tissue samples using NMR metabolomics. Metabolomics 3, 55-67 (2007).

Y. Xi, J. de Ropp, M. R. Viant, D. L. Woodruff and Ping Yu, Automated Identification of Metabolites in Complex Mixtures by Pseudo-likelihood using 2D COSY NMR Spectroscopy. Metabolomics 2, 221-233 (2006).

E. S. Rosenblum, R. S. Tjeerdema and M. R. Viant, Effects of Temperature on Host-Pathogen-Drug Interactions in Red Abalone, Haliotis rufescens, Determined by 1H NMR Metabolomics. Env. Sci. Technol. 40, 7077-7084 (2006).

M. R. Viant, C. A. Pincetich and R. S. Tjeerdema, Metabolic effects of dinoseb, diazinon and esfenvalerate in eyed eggs and alevins of Chinook salmon (Oncorhynchus tshawytscha) determined by 1H NMR metabolomics. Aquat. Toxicol. 77, 359-371 (2006).

M. R. Viant, C. A. Pincetich, D. E. Hinton and R. S. Tjeerdema, Toxic Actions of Dinoseb in Medaka (Oryzias latipes) Embryos as Determined by in vivo 31P NMR, HPLC-UV and 1H NMR Metabolomics. Aquat. Toxicol. 76, 329-342 (2006).

M. R. Viant, B. G. Lyeth, M. G. Miller and R. F. Berman, An NMR Metabolomic Investigation of Early Metabolic Disturbances Following Traumatic Brain Injury in a Mammalian Model, NMR in Biomedicine 18, 507-516 (2005).

G. D. Stentiford, M. R. Viant, D. G. Ward, P. J. Johnson, A. Martin, W. Wei, H. J. Cooper, B. P. Lyons and S. W. Feist, Liver tumours in wild flatfish: a histopathological, proteomic and metabolomic study, OMICS - Journal of Integrative Biology 9, 281-299 (2005).

E.S. Rosenblum, M. R. Viant, B. M. Braid, J. D. Moore, C. S. Friedman and R. S. Tjeerdema, Characterizing the Metabolic Actions of Natural Stresses in the California Red Abalone, Haliotis rufescens using 1H NMR Metabolomics. Metabolomics 1, 199-209 (2005).

M. R. Viant, J. G. Bundy, C. A. Pincetich, J. S. de Ropp and R. S. Tjeerdema, NMR-Derived Developmental Metabolic Trajectories: An Approach for Visualizing the Toxic Actions of Trichloroethylene during Embryogenesis. Metabolomics 1, 149-158 (2005).

C. A. Pincetich, M. R. Viant, D. E. Hinton and R. S. Tjeerdema, Metabolic Changes in Japanese Medaka (Oryzias latipes) during Embryogenesis and Hypoxia as determined by in vivo 31P NMR, Comp. Biochem. Physiol. C 140, 103-113 (2005).

P. V. Purohit, D. M. Rocke, M. R. Viant and D. L. Woodruff, Discrimination Models using Variance Stabilizing Transformation of Metabolomic NMR Data, OMICS - Journal of Integrative Biology 8, 118-130 (2004).
Note: there is an error in equation 1. Please email Mark Viant for further details.

M. R. Viant, I. Werner, E. S. Rosenblum, A. S. Gantner, R. S. Tjeerdema and M. L. Johnson, Correlation Between Heat-Shock Protein Induction and Reduced Metabolic Condition in Juvenile Steelhead Trout (Oncorhynchus mykiss) Chronically Exposed to Elevated Temperature, Fish Physiol. Biochem. 29, 159-171 (2003).

M. R. Viant, E. S. Rosenblum and R. S. Tjeerdema, NMR-Based Metabolomics: A Powerful Approach for Characterizing the Effects of Environmental Stressors on Organism Health, Env. Sci. Technol. 37, 4982-4989 (2003).

M. R. Viant, Improved Methods for the Acquisition and Interpretation of NMR Metabolomic Data, Biochem. Biophys. Res. Comm. 310, 943-948 (2003).

M. R. Viant, C. A. Pincetich, J. H. Walton, R. S. Tjeerdema and D. E. Hinton, Utilizing in vivo Nuclear Magnetic Resonance Spectroscopy to Study Sublethal Stress in Aquatic Organisms, Mar. Environ. Res. 54, 553-557 (2002).

M. R. Viant, J. H. Walton, P. L. TenBrook and R. S. Tjeerdema, Sublethal Actions of Copper in Abalone (Haliotis rufescens) as Characterized by in vivo 31P NMR, Aquat. Toxicol. 57, 139-151 (2002).

M. R. Viant, E. S. Rosenblum and R. S. Tjeerdema, Optimized Method for the Determination of Phosphoarginine in Abalone Tissue by High-performance Liquid Chromatography, J. Chromatogr. B 765, 107-111 (2001).

M. R. Viant, J. H. Walton and R. S. Tjeerdema, Comparative Sublethal Actions of 3-Trifluoromethyl-4-nitrophenol in Marine Molluscs as Measured by in vivo 31P NMR, Pestic. Biochem. Physiol. 71, 40-47 (2001).